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Allergic reaction triage

Primary care triage for allergic reactions with immediate recognition of anaphylaxis risk and escalation triggers.

Last reviewed February 7, 2026

Red flags

  • Airway compromise, respiratory distress, hypotension, or multisystem progression.
  • Rapid symptom escalation after likely allergen exposure.
  • Refractory symptoms or biphasic reaction concern after initial stabilization.

Assessment priorities

  • Determine trigger exposure timing, symptom pattern, and airway involvement.
  • Assess breathing, circulation, skin/mucosal findings, and GI symptoms rapidly.
  • Clarify prior anaphylaxis history and epinephrine access.

Initial management

  • Suspected anaphylaxis requires immediate IM epinephrine and 911 activation; see the allergic-reaction workflow for dosing and repeat treatment. Do not wait for skin findings or hypotension.
  • Keep the patient supine with legs elevated where tolerated; do not allow standing/walking. Antihistamines and inhalers must not delay epinephrine or emergency transfer.
  • For non-severe reactions, provide symptom control with close observation strategy.
  • Document clear trigger-avoidance and emergency action instructions.

Follow-up and escalation

  • Transfer suspected anaphylaxis for hospital assessment even after improvement; hospital teams determine observation duration.
  • Escalate immediately for any airway, breathing, or circulation deterioration.
  • Arrange allergy-focused follow-up for trigger confirmation and prevention planning.

References