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Iron deficiency anemia referral checklist

Baseline labs, red flags, and referral note elements for iron deficiency anemia workup.

Last reviewed 2026-01-05|anemia | hematology | workup

Minimum pre-referral workup

  • CBC with indices and reticulocyte count if available.
  • Ferritin and iron studies (transferrin saturation).
  • B12 and folate if macrocytosis or mixed picture.
  • Review for bleeding sources and medication contributors (NSAIDs, anticoagulants).
  • Consider celiac serology if iron deficiency is unexplained.

Urgency tier

  • Hemodynamic instability or syncope.
  • Hemoglobin less than 80 g/L or rapidly dropping hemoglobin.
  • Melena, hematemesis, or significant GI bleeding.
  • New dysphagia, weight loss, or systemic symptoms.
  • Pregnancy with symptomatic anemia.

Referral packet checklist

  • Duration of anemia and symptoms (fatigue, dyspnea, pica).
  • Menstrual history, GI symptoms, and bleeding risk factors.
  • Complete lab trend summary with ferritin and iron indices.
  • Response to oral iron or intolerance.
  • Relevant comorbidities and current medications.

Pre-referral optimization tasks

  • Start or continue iron replacement when appropriate and tolerated.
  • Investigate and mitigate active bleeding sources manageable in primary care.
  • Reinforce urgent return precautions for syncope, chest pain, or ongoing significant bleeding.