Hestia criteria (outpatient PE)

Hemodynamic instability or need for vasopressors

Requires thrombolysis or embolectomy

Active bleeding or high bleeding risk

Requires supplemental oxygen >24 hours to keep SpO2 > 90%

Requires IV analgesia for pain control

PE occurred while on therapeutic anticoagulation

Severe renal impairment (CrCl < 30 mL/min)

Severe liver impairment

Platelets < 100 x 10^9/L

Pregnant or postpartum < 6 weeks

Medical or social reason for admission